Formulation and Optimization of Stable Floating Tablet of Losartanpotassium for Oral Controlled Drug Delivery System

The present study was to prepare a gastro retentive drug delivery system of Losartan floating tablets, was designed to increase the gastric residence time, thus prolong the drug release. The different type formulations were prepared by using polymers like HPMC K100M, ethyl cellulose, talc and lactose. In the present study Sodium bicarbonate and citric acid were incorporated as a gas generating agent. The Floating tablets were evaluated for pre compression and post compression parameters. And optimisation of formula. The drug release profile and floating properties was investigated. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 8-12 hours. From the study it is concluded that the developed formulation has good appearance with good handling condition, therapeutically efficacious, stable.